Immunoregulation effects of TIM-3 on tumors
نویسندگان
چکیده
منابع مشابه
Lack of TIM-3 immunoregulation in multiple sclerosis.
Multiple sclerosis (MS) is an inflammatory disease of the CNS white matter associated with T cell infiltrates and alterations of immune functions that can be measured in the peripheral immune system. TIM-3 has been identified as a central regulator of IFN-gamma-secreting type 1 Th (Th1) cells and immune tolerance. In this study, using a newly generated mAb against human TIM-3, we examined TIM-3...
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Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has been reported to negatively regulate the immune responses against viral infection and had implications for autoimmune disease. However, the nature and role of Tim-3(+) CD4 T cells in human tumors remain largely unknown. In the present study, we characterized Tim-3(+) CD4 T cells in 100 specimens from human hep...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2019
ISSN: 1338-4317
DOI: 10.4149/neo_2018_180610n385